Overlapping and distinct neural activation during reward and loss processing
A meta-analysis published in Human Brain Mapping.
By Stuart Oldham et al.
Reward and loss processing are essential factors in decision making, allowing us to obtain a reward or avoid a loss respectively. These process can be broken down into two key stages- an anticipation stage where a potential reward/loss is first encountered, and an outcome phase where the reward/loss is obtained or omitted. Past neuroimaging studies have been in disagreement as to how neurally distinct the stages of these different processes are.
To address this, we conducted a meta-analysis of 50 neuroimaging studies that had used the Monetary Incentive Delay Task, which is considered a prototypical paradigm for assessing the different stages of reward/loss processing. We found that when anticipating a reward or a loss, overlaps in activation could be observed in striatal-thalamic, insula, and amygdala regions of the brain. This suggests that a more generalised neural system, potentially responsible for instigating motivational responses, underlies the anticipation phase of both processes.
We also found that orbitofrontal/ventromedial prefrontal regions were active when a reward was received, but not when a reward was anticipated, indicating these areas are likely involved in representing the value of the received reward. Overall our results help to shed light on the neurobiology of reward and loss processing.
Summary of main results. (a) Activation during reward anticipation. (b) Activation during loss anticipation. (c) Activation during reward outcome. The colourbar indicates the probability of activation in a given voxel.
Oldham, S., Murawski, C., Fornito, A., Youssef, G., Yücel, M., & Lorenzetti, V. (2018). The anticipation and outcome phases of reward and loss processing: A neuroimaging meta-analysis of the monetary incentive delay task. Human Brain Mapping. Doi: 10.1002/hbm.24184
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